Tissue Lysates
Cayman Chemical SynthetIc PF-1022A 1mg
A cyclodepsipeptide with anthelmintic activity; oral administration induces worm excretion in a chicken model of A. galli infection from 0.5-2 mg/kg; induces parasite clearance in jird models of H. contortus, O. ostertagi, or T. colubriformis infection (ED95s = 0.11, 0.33, and 0.11 mg/animal)
Cayman Chemical nospIramycIn I 1mg
A macrolide antibiotic; active against the macrolide-sensitive KB210 strain of S. aureus (MIC = 3.12 UG/ml), as well as B. cereus, B. subtilis, M. luteus, E. coli, and K. pneumoniae (MICs = 1.56, 3.12, 3.12, 0.2, 50, and 12.5 UG/ml, respectively; binds to E. coli ribosomes (IC50 = 1.2 µM); protects against mortality in a mouse model of S. pneumoniae type III infection (ED50 = 399.8 mg/kg)
Cayman Chemical 11-nor-9-carboxy CnabInol 1mg
An analytical reference standard categorized as a phytocannabinoid metabolite; a metabolite of cannabinol; intended for research and forensic applications
Cayman Chemical SynthetIc Curzeren 1mg
A sesquiterpene with diverse biological activities; scavenges DPPH radicals in a cell-free assay at 3.36 UG/L with a synergistic effect when used in combination with eucalyptol; active against F. graminearum at 0.5 mg/ml; inhibits the proliferation of SK-MEL-19 melanoma cells (IC50 = 5.17 UG/ml), as well as AGP-01 gastric and HCT116 colon cancer cells (IC50s = 8.04 and 9.18 UG/ml, respectively) and MRC-5 non-cancerous human fibroblasts (IC50 = 11.45 UG/ml); induces apoptosis in, and decreases migration of, SK-MEL-19 cells at 5 and 10 µM; reduces tumor weight in an SPC-A1 mouse xenograft model at 135 mg/kg
Cayman Chemical SynthetIc SpongosIn 1mg
A nucleoside with diverse biological activities; antagonist of adenosine A1, A2A, and A3 receptors (Kis = 155, 970, and 156 nM, respectively, in CHO cells expressing the human receptors); inhibits collagen-induced platelet aggregation in isolated human whole blood and platelet-rich plasma at 100 µM; decreases contractile force and frequency in spontaneously contracting isolated guinea pig atrial muscles (EC50s = 32.7 and 127.7 µM, respectively)
Cayman Chemical SynthetIc AvIcularIn 1mg
A flavonoid glycoside with diverse biological activities; inhibits FASN and aldose reductase (IC50s = 6.15 and 19.05 µM for the chicken liver and human enzymes, respectively); scavenges DPPH and superoxide radicals, as well as inhibits copper-induced oxidation of LDL in cell-free assays (IC50s = 64.3, 6, and 3.8 µM, respectively); inhibits LPS-induced increases in NO and PGE2 production in RAW 264.7 macrophages at 30-300 µM; inhibits the proliferation, migration, and invasion of, as well as induces apoptosis and cell cycle arrest at the G0/G1 phase in, Huh7 cells at 100 UG/ml
Cayman Chemical SIamycIn I 1mg
A tricyclic peptide with antiviral and antibacterial activities; active against laboratory strains and clinical isolates of HIV-1 (ED50s = 0.05-0.45 and 0.89-5.7 μM, respectively), as well as the CBL-20 strain of HIV-2 (ED50 = 0.45 μM), in vitro; inhibits HIV-induced fusion of C8166 T cells with HIV-1-infected CEM-SS cells (ED50 = 0.08 μM); active against B. subtilis, M. luteus, and S. aureus (MICs = 1.6-6.3 μg/ml); inhibits GBAP-induced autophosphorylation of the E. faecalis quorum sensing kinase FsrC
Cayman Chemical 1 3DIaLInolenoyl Glycerol 1mg
A diacylglycerol; has been found in the roots of A. sinensis and the aerial part of H. halodendron
Cayman Chemical EZ-T-603 1mg
A mixture of (E)-IT-603 and (Z)-IT-603; (Z)-IT-603 is a c-Rel inhibitor (IC50 = 3 µM); (Z)-IT-603 inhibits c-Rel DNA binding in an EMSA; preincubation with mouse T cells prevents the development of GVHD but does not affect GVT activity in a mouse model of allogeneic hematopoietic stem cell transplantation at 20 µM
Cayman Chemical IsoastragalosIde I 1mg
A saponin with diverse biological activities; inhibits LPS-induced production of NO, TNF-α, and IL-1β, as well as inhibits NF-κB phosphorylation in BV-2 microglia from 25-100 µM; induces adiponectin production in 3T3-L1 adipocytes from 2-10 UG/ml; induces the expression of β-cell differentiation genes and increases mRNA levels of Ngn3 and the β-cell markers insulin1 and insulin2 in mPDOs